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leprae. Anin silicostudy was conducted to know the molecular interactions in between DNA gyrase and WQ compounds. WQ-3334 and WQ-3810 had been demonstrated to own better inhibitory activity againstM. lepraeDNA gyrase than Many others. In addition, Evaluation using quinolone-resistantM. lepraeDNA gyrases showed that WQ-3334 had bigger inhibitory act